Pepperoni pizza served with buffalo wings
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Welcome to Wise Guys Pizza

Buffalo Style Pizza • Wings • Late Night • South Buffalo

Skip the wait, call it in: (716) 826-8406

Sheet One Topping Pizza & 50 Wings

Welcome to Wise Guys Pizza

A family-owned staple rooted on historic seneca street. we serve the south buffalo classics—hand-crafted pies, crispy wings, and hearty subs made with a whole lot of love. whether you’re heading to the bills game or hunkering down for a blizzard, we’re here to keep the neighborhood fed.

Our Handpicked favorites!


Crispy buffalo chicken wings with ranch dip

BUFFALO STYLE CHICKEN WINGS

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SANDWICHES, SUBS, & HOAGIES

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BUFFALO STYLE PIZZA

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You Host, We Cook.

Whether you're hosting a game day at the house, a corporate lunch on Seneca Street, or a family milestone, Wiseguys has you covered. We specialize in feeding the neighborhood with party-sized portions of our hand-crafted pizza, crispy wings, and hearty subs.

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🍕 Join Our Team

We’re always looking for reliable, friendly people to join our crew. If you’re a hard worker who loves the South Buffalo community, we’d love to meet you.

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🎁 Gift Cards

The easiest way to share a South Buffalo favorite. Perfect for birthdays, holidays, or just saying thanks with a local slice.


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📩 Newsletter

Sign up to get the latest Seneca Street deals and Wiseguys news sent straight to your inbox. No spam, just pizza.


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LOCATION

1965 Seneca St., Buffalo, NY 14210


HOURS


Monday - Saturday: 10am - 11pm

Sunday: 10am - 9pm


CALL US

(716) 826-8406


Reviews

I flew to Buffalo to eat pizza for 3 days. Of all the photos I've seen of Buffalo pizza, the Wise Guys photos always looked the best. This was my first stop after I landed this morning and this was the pizza. When I first saw the thickness of the pepperoni, I thought it was going to be a little too thick for me but when I tasted it at the temperature they cooked it at; this is the perfect thickness for this char and this pizza. Jasmine told me she made it with pride for me. Pride? This thing was made by the gods on Mount Vesuvius! Bocce Club has a big hill to climb tomorrow. For the record, I ordered a pepperoni with the crushed red pepper crust

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Ralph G.

Best pizza in the south. They are a hometown must. Chicken fingers are by far the best in wny!! So many flavors to choose from!! House bluecheese is a must have!! And that classic Buffalo ny tasting pizza reminds me of being a kid. Thank you for making such great food!!

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SP G.

Spectacular pizza so greasy so cheesy sweet sause outstanding wings to so big and juicy my mind was blown definitely would come back not much for sitting area but great hospitality

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Peter G.

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