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  • WiseGuys Pizza Buffalo

Wise Guys Pizza restaurant banner with city skyline

WiseGuys Pizza Buffalo

1965 Seneca St., Buffalo, NY
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Buffalo Pizza & Wing Combos
Slices
Beverages
Breakfast Pizza
Buffalos Best Specialty Pies
Buffalo Style Pizzas
Buffalo Style Hoagies
Buffalo's Best Chicken Wings
Buffalo Boneless Wings
Buffalos Style Chicken Tenders
Salads
Garlic Breads
Calzone
Buffalo's Best Catering Menu
Buffalo's Fry Zone
Buffalo Style Pizza Logs/Crunch Wraps
Buffalo Signature Sides
MaryJanes Desserts
Subs
(4) Mozzarella Planks

Featured Items

  • Buffalos best Chicken Wings

    Buffalo’s best hot wings, BBQ, Honey Mustard, Loganberry and more — tossed the way the 716 likes it. Crispy, saucy, and finished with our homemade blue cheese because ranch ain’t the boss here. South Buffalo flavor on every bite.
  • Buffalo Style Pizza

    Mouth-watering Buffalo-style pizza since 1992 🔥🍕 Made the way the old man taught us — crispy, cheesy, no shortcuts. Personals. Larges. X-Large. Sheet Pizzas. Gluten-Free. However you want it… we’re cooking.
  • Buffalo Pizza & Wing Combos

    Hot pizza. Saucy wings. A combo that hits harder than a Sunday night kickoff 🔥🍕 Whether you’re hosting Bills parties, grad parties, or just dinner with the kids — Wiseguys Pizza & Wing Combos bring the flavor every time. Big boxes, bold Buffalo taste, zero stress.

Buffalo Pizza & Wing Combos

  • Buffalo Pizza & Wing Combos

    Hot pizza. Saucy wings. A combo that hits harder than a Sunday night kickoff 🔥🍕 Whether you’re hosting Bills parties, grad parties, or just dinner with the kids — Wiseguys Pizza & Wing Combos bring the flavor every time. Big boxes, bold Buffalo taste, zero stress.

Slices

  • 2 SLICES CH/PEP & CAN OF COKE

    The biggest slices you’ll find on Seneca Street. 🍕 First come, first served — so we recommend ordering ahead!
    $8.50
  • Pepperoni Pizza Slice

    Gooey cheese, cup-n-char, sweetened sauce — just the way Buffalo pizza should be. 🍕🔥
    $4.60

Beverages

  • Beverages

    Nothing hits like an ice-cold Coca-Cola with a hot Buffalo-style pizza 🧊🥤🍕 Whether you’re grabbing slices, feeding the family, or loading up for game day — crack open a frosty Coke and let Wiseguys handle the flavor. Because great pizza deserves an ice-cold partner.

Breakfast Pizza

  • Buffalo Best Breakfast Pizza

    Breakfast done the Wiseguys way 🔥🍳 Fluffy eggs, crispy bacon, savory ham — loaded with melted yellow American, mozzarella & cheddar, all sitting on a rich homemade gravy base. Creamy, cheesy, and straight comfort-food energy. One bite and you already know… this ain’t your average morning.

Buffalos Best Specialty Pies

  • Buffalos Best Specialty Pies

    When the basics ain’t smacking… it’s time to level up 😎🍕 A whole lineup of Buffalo-style specialty pizzas — bold flavors, real attitude, available in ALL sizes. Go ahead… surprise yourself and try something different tonight.

Buffalo Style Pizzas

  • Buffalo Style Pizza

    Mouth-watering Buffalo-style pizza since 1992 🔥🍕 Made the way the old man taught us — crispy, cheesy, no shortcuts. Personals. Larges. X-Large. Sheet Pizzas. Gluten-Free. However you want it… we’re cooking.

Buffalo Style Hoagies

  • Buffalo Style Hoagies

    Finely chopped steak, seasoned chicken, Italian sausage, turkey & more stacked high with fresh sautéed onions — peppers and mushrooms if you’re feeling dangerous 😈🔥 Finished the Buffalo way on a toasted hoagie roll with melty cheese and straight street-corner attitude. Big. Messy. Built like a true 716 classic. Available on an 8", 12", or a seeded 18" roll… because around here we don’t do small energy 🍞💪

Buffalo's Best Chicken Wings

  • Buffalos best Chicken Wings

    Buffalo’s best hot wings, BBQ, Honey Mustard, Loganberry and more — tossed the way the 716 likes it. Crispy, saucy, and finished with our homemade blue cheese because ranch ain’t the boss here. South Buffalo flavor on every bite.

Buffalo Boneless Wings

  • 716 Buffalos Best Boneless Wings

    🍗 Boneless Wings… SouthBuffalo style, no excuses 🔥 Right here on Seneca Street, we’re tossing ‘em crispy, saucy, and reckless — from Hot 🔥 to Honey Mustard 🍯 to Loganberry 🍒 and everything in between. Perfect for game day, dinner with the kids, or when you just don’t feel like fighting with bones 😏 #SouthBuffalo #SenecaStreet

Buffalos Style Chicken Tenders

  • Buffalos Style Chicken Tenders

    Don’t overthink it — sometimes you just need crispy Buffalo-style chicken fingers done right 🔥🍗 Golden fried, juicy inside, and ready to be dunked in whatever sauce matches your mood. Lunch, dinner, game night… or when cooking sounds like a bad life choice.

Salads

  • Salads

    Homemade salads like grandma made every summer 🥗 Chef, Antipasto, Chicken Finger, Grilled Chicken, Souvlaki, Steak & more — fresh, stacked, Buffalo bold.

Garlic Breads

  • Garlic Breads

    Golden garlic breads, soft pretzel sticks, dessert breadsticks, classic breadsticks — hot, buttery, and straight-up irresistible 🔥🥖 Crispy edges, fluffy centers, and that Buffalo-style flavor that hits different. Perfect for dipping, sharing… or not. South Buffalo cravings start here.

Calzone

  • Calzone

    Ricotta. Mozzarella. Folded, fired, and built like a straight-up Wiseguys weapon 🔥🥟 Our Calzone comes loaded with creamy ricotta and melty mozzarella — then you make it dangerous… add any toppings you want for that extra charge and extra attitude. Buffalo-style comfort with a criminal record.
    $15.25

Buffalo's Best Catering Menu

  • Buffalos Best Catering Menu

    Choose your weapons the Wiseguys way 🍝🔥 Pastas, Pizza Packs, Chicken Wings, Boneless, Chicken Fingers, Subs & Wraps — stack it up with ANY side, ice-cold drinks to quench the thirst, and don’t forget the desserts to finish the job. 🎉 Having a party? Grad parties, Super Bowl parties, youth sports events, business meetings — we got you covered with catering. Just give us 24-hour notice and we’ll handle the rest, South Buffalo style.

Buffalo's Fry Zone

  • Buffalos Fry Zone

    🍟 Hot. Crispy. Shake-worthy. 🍟 Our French Fries don’t just show up… they show OFF. Upgrade to Specialty Fries or get ‘em Shaken in your favorite wing sauce — sweet, spicy, buffalo, or straight savage 🔥 Perfect for Bills parties, late-night cravings, or stealing a few off your kid’s plate (we won’t tell 😏).

Buffalo Style Pizza Logs/Crunch Wraps

  • Buffalo Style Pizza Logs/Crunch Wraps

    Crunch Wraps & Pizza Logs — Buffalo Style Trouble 🔥🌯 Our Classic Pizza Logs (4ct) come crispy and ready to be shaken in ANY homemade wing sauce — because basic ain’t our style. The Crunch Wrap lineup is straight dangerous: Steak & Cheese, Mac & Cheese, Sausage & Hot Pepper, and Buffalo Chicken… all melty, messy, and built for dipping. South Buffalo flavor with street-corner attitude — choose your sauce and get reckless.

Buffalo Signature Sides

  • Buffalos Signature Sides

    Don’t forget the little things that make a BIG difference 🍕🔥 Need plates, napkins, forks, ketchup, blue cheese, ranch or all the extras? We got you covered — because real Wiseguys know the setup matters just as much as the food. Perfect for parties, game day, or dinner with the crew.

MaryJanes Desserts

  • MaryJane's Desserts

    🍰 Sweet cravings don’t stand a chance at MaryJane’s Desserts 😍 Fried Dough… Cheesecake… Cannolis… Chocolate… Red Velvet — and honestly, who knows what she’s gonna come up with next 🔥 If you’ve got a sweet tooth, consider this your warning… once you start, there’s no turning back.

Subs

All subs are made with White Costanzo's Rolls. They come with a choice of Cheese, Lettuce, Tomatoes, and Onions unless otherwise specified. Baked subs do not include produce. (We don't split whole subs)
  • 12" Assorted

    ham, salami, and capicola
    $14.25
  • 12" Capicola

    Margherita capicola
    $14.25
  • 12" Cheese

    baked on request
    $13.25
  • 12" Ham & Turkey

    Sahlen’s ham & premium turkey
    $14.25
  • 12" Ham

    Sahlen’s smoked ham
    $14.25
  • 12" Salami

    Margherita Salami
    $14.25
  • 12" Turkey

    $14.25
  • 12" Royal Sausage & Capicola

    $16.25
  • 12" Baked Sicilian

    Sausage, bacon, mozzarella & parmesan baked on garlic bread with fried onions and your choice of peppers
    $16.25
  • 12" Steak Sub

    3 Pieces of U.S.D.A Ribeye steak, NOT CHOPPED, Grilled to perfection.
    $15.25
  • 12" Chicken Finger Sub

    $15.25
  • 12" Chicken Finger Club

    with bacon
    $16.25
  • 12" Baked Chicken Parm

    $15.25
  • 12" Chicken Souvlaki

    Includes chicken, lettuce, tomato, onion, black olives, feta, and Greek dressing.
    $16.25
  • 12" Italian Sausage

    $15.25
  • 12" Baked Meatball

    $15.25
  • 12" Pepperoni Pizza Sub

    mozzarella & pepperoni
    $13.25
  • 12" Bacon Cheese Burger Sub

    $17.25
  • 12" BLT

    $14.25
  • 12" Cheeseburger Sub

    $15.25
  • 12" Baked Chicken Bacon Ranch

    $16.25
  • 12" Hitman

    sausage, capicola, ham & salami (hot sauce optional)
    $17.25

(4) Mozzarella Planks

  • (4) Mozzarella Planks

    4 Mozzarella Planks — Buffalo style 🔥🧀 Crispy, melty, and built like a lake-effect snowstorm… big, bold, and no holding back. Served up golden and ready to dip like a true 716 legend.
    $10.75

WiseGuys Pizza Buffalo Location and Hours

(716) 826-8406
1965 Seneca St., Buffalo, NY 14210
Closed • Opens Tuesday at 10AM
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